By the age of 15, Ajram signed a recording contract with EMI and released her debut studio album Mihtagalak (1998).
In spite of being under the legal age, Ajram was exceptionally accepted to the Syndicate of Professional Artists in Lebanon.
Ajram studied music with renowned Lebanese musicians and although she was less than 18 years old, the syndicate of professional artists in Lebanon accepted her as a member. The first was "Hobbak Allam Albi El Gheere", written by Antoine Harfouch and composed by Abdo Mounzer. At the age of 15, Ajram released her debut album, Mihtagalak, followed by Sheel Oyoonak Anni three years later.
In early 2002, Ajram signed a contract with renowned Lebanese producer and artist manager Jiji Lamara, four months after his splitting with Aline Khalaf.
In late April, Ajram opened for Enrique Iglesias's first concert in Egypt in 2004.
Ajram then filmed "Lawn Ouyounak" (Color of Your Eyes), which portrayed Ajram as a bride in a traditional Lebanese wedding.
She was described on The Oprah Winfrey Show as one of the most influential personalities of the Middle East, and she described her as Britney Spears of the Middle East.
Ajram has made the list of Most Powerful Arabs on Arabian Business several times, and was similarly listed by Newsweek as one of the most influential Arabs.
In 1995, at the age of twelve, Ajram took part in a variety show, Noujoum Al-Moustakbal (English: Stars of the Future) on Future TV, a Lebanese reality television competition, which finds new solo musical talent.
Ajram won a gold medal in the Tarab category after singing a song by Umm Kulthum.
They started working together in preparation for the third studio album shifting her musical style and image away from the decent girl.
Ajram's breakthrough single, "Akhasmak Ah", was released in December, The music video caused a controversy; reminiscent of older Arabic films, she appeared as a cafe manager who dances and flirts with its customers.
She then filmed with Fadi Haddad, the director of photography of her previous works with El Marouk, a video for the song "Risala Lil Aalam" (A Message to the World) which talks about world peace.