Prostaglandins are chemicals that contribute to inflammation especially within joints, and it is the inflammation that leads to the common symptoms of pain, tenderness, and swelling associated with arthritis.Meloxicam blocks the enzymes that make prostaglandins (cyclooxygenase 1 and 2) and reduces the levels of prostaglandins.These enzymes help to make other chemicals in the body, called prostaglandins.
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Meloxicam is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs) that are used to treat pain and/or inflammation.
Other members of this class include ibuprofen (Motrin), indomethacin (Indocin), nabumetone (Relafen) and several others.
This may occur because prostaglandins play a role in the regulation of blood pressure.
When meloxicam is used in combination with methotrexate (Rheumatrex, Trexall) or aminoglycosides (for example, gentamicin) the blood levels of the methotrexate or aminoglycoside may increase, presumably because their elimination from the body is reduced.
Because meloxicam may cause a fetal birth defect called ductus arteriosus (early closure of two major blood vessels of the heart and lung) in the third trimester of pregnancy, meloxicam also should be avoided during this last part of pregnancy.
There have been no studies in humans to determine if meloxicam is excreted in breast milk.Meloxicam eases pain and swelling (inflammation) in long-term conditions like rheumatoid arthritis and ankylosing spondylitis, but it may also be used for a shorter period of time in osteoarthritis.Meloxicam works by blocking the effect of natural chemicals called cyclo-oxygenase (COX) enzymes.Cholestyramine (Questran), colestipol (Colestid), and colesevelam (Welchol) may decrease the effectiveness of meloxicam by preventing its absorption from the intestine. Combining sodium polystyrene sulfonate (Kayexalate) with sorbitol may cause fatal intestinal necrosis.Therefore, meloxicam oral solution should not be combined with Kayexalate.Some patients require a dose of 15 mg daily, but this larger dose should be taken only under the direction of a physician.